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Coronavirus: What it Does To The Body

By Anne Goffard | Source
Physician, University Professor – Hospital Practitioner,
University of Lille


After SARS in 2003 and MERS in 2012, a new coronavirus, called 2019-nCoV, is of concern to international health authorities. A cousin of SARS and probably descended from a bat virus, it is believed to have emerged in early December in Wuhan, China.

As of January 30, 2020, 7891 infections have been confirmed in some 20 countries, resulting in 170 deaths, so far only on Chinese soil. What are the causes of these deaths? How do coronaviruses make us sick? Are there predispositions to these infections?

Over 100 Coronavirus cases confrmed in US, more deaths in Washigyon State

Medically, there are two groups of coronaviruses: low pathogenic coronaviruses (there are currently four), and highly pathogenic coronaviruses, of which only two representatives are currently known, SARS-CoV (severe acute respiratory syndrome) and MERS-CoV.

At present, the available data are too incomplete to state that the virus that emerged in Wuhan belongs to either of these categories. More information will have to be obtained, particularly from the Chinese health authorities.

Low pathogenic coronaviruses circulate in USA every year, in autumn, throughout the winter and in spring, but disappear during the summer. For these viruses as for other seasonal viruses (flu, colds, gastroenteritis…), the reasons for this summer break are not well known.

It is likely that remaining confined to buildings in winter facilitates the transmission of viruses. What’s more, weather conditions certainly play a role. No precise mechanism has yet been identified, but it is known, for example, that some viruses such as influenza seem to be less resistant to hot air than to cold, dry air. In addition, dry air weakens the nasal mucosa, making it easier for respiratory viruses such as coronaviruses to penetrate.

The Nose, The Gateway to Coronaviruses

When a person infected with a coronavirus sneezes, droplets of nasal secretions loaded with viral particles are sprayed around them, with the thinner ones (aerosols) travelling further than the larger ones. At this time, it is not known whether 2019-nCoV is transmitted by aerosol or whether only the larger droplets are infectious. However, it appears to be better transmitted than SARS or MERS-CoV, which surprisingly has not spread beyond the Arabian Peninsula.

If a healthy person is affected by the splashes and breathes in droplets containing coronavirus, a new infection begins. Initially, the viruses enter the nasal cells through a protein “key”: the S-protein (Spike). This protein is present in numerous copies on the surface of the virus and gives it the “crown” appearance to which it owes its name, coronavirus.

This “key” interacts with a “lock” on the surface of human cells, allowing the virus to cling to it and then enter. Not all coronaviruses have the same types of keys, and therefore do not recognize the same locks. However, because these locks are essential to the functioning of our bodies, we all have them inside us. So we are all susceptible to coronavirus infection.

Why is the Progression of Coronavirus Infection Sometimes Fatal?

A first surprise is the severity of the disease in terms of radiological damage. Three-quarters of hospitalized patients have radiological damage to both lungs: this very frequent bilateral pneumonia attests to the respiratory pathogenicity of the virus in question and its ability to cause acute respiratory failure.

Patients who progress badly (frequently: age over 60 years, massive exposure at the market place, smoking, chronic pathologies) develop severe bilateral pneumonia with lesional alveolar oedema (i.e. the alveoli of the lungs are infiltrated with serosities), acute respiratory insufficiency (there is no longer enough oxygen passing through the blood), cardiocirculatory disorders (drop in blood pressure, low microcirculatory flow rates) and subsequent multi-viscular failure. The pulmonary damage and the cardiovascular consequences are such that, despite the implementation of heavy resuscitation techniques, the evolution is sometimes fatal (acute respiratory distress syndrome with hemodynamic, i.e. cardiocirculatory, disorders).

In conclusion, this new epidemic of respiratory coronavirus 2019-nCoV infection is especially worrying in countries with a low level of individual and collective prevention (lifestyle and microbial hygiene). It must be noted that the level of hygiene in China is low. And the World Health Organization (WHO) is mainly concerned that the virus may reach other countries with a low level of hygiene: this is the main risk at the global level.

Multivisceral Failures

Once inside a cell, the coronavirus hijacks it and forces it to produce a large number of copies of itself. After a relatively short time, 6 or 8 hours later, these copies come out of the infected cell (usually by destroying it) and attack its neighbours.

If the infection is due to a low pathogenic coronavirus, the symptoms, for a healthy person, are usually those of a cold.

The problem is that the locks that allow coronaviruses to enter the cells of the respiratory tract are also present on the cells of other organs, such as the kidneys or intestines. So coronaviruses can infect them too. In this, coronaviruses differ from influenza viruses, which only recognize structures present on cells of the respiratory tract. This explains why influenza does not give any signs in the kidneys or intestines.

In the case of highly pathogenic viruses such as MERS or SARS, the affected organs can be severely damaged. In addition to severe lung failure, which causes respiratory distress, patients sometimes suffer from kidney failure (which will require dialysis), heart failure, etc. Unfortunately, the transfer to intensive care is not always sufficient, and some die.

The knowledge accumulated following the SARS and MERS epidemics has led to a better understanding of the factors that influence the outcome of the infection. Of particular importance is the relationship between the coronavirus and the patient’s immune system.

The Elderly And Immunocompromised Are Most At Risk

It is known that people who are more prone to complications are those who are immunocompromised (due to illness or medical treatment) or whose immune systems are less well-functioning, such as the elderly. The virus takes advantage of these deficiencies and replicates better.

For example, a few years ago, a patient undergoing immunosuppressive treatment for transplantation died from an infection with MERS-CoV. Muzzled to prevent him from rejecting the transplant, his immune system could not contain the viral infection, which had spread to all organs.

Conversely, young people, whose immune system is very effective, are generally less affected. Thus, for MERS-CoV, almost no contamination of children has been described; rather, it is a disease of adults and the elderly.

The situation was different in the case of SARS: not only was its case-fatality rate higher than that of MERS, but the virus also caused the death of young patients.

2019-nCoV: A Lack Of Information

Initial information about the new coronavirus suggests that deaths are occurring in very old people who already have other conditions. Other people appear to be recovering fairly quickly, which would explain why there are currently “only” 170 deaths out of more than 7,800 officially reported infections.

However, there is still a lack of information, and some of the information available seems different from the observations made on patients whose disease has been declared in Sweden. Thus, the first information disseminated by Chinese doctors seemed to indicate the existence of pneumopathy, i.e. a low lung infection.

However, some of the patients hospitalized in United States do not seem to develop this type of lung tissue damage. In their case, the infection remains in the upper respiratory tract, mainly in the nose and probably in the throat and sinuses. The situation would therefore be different, for example, from a MERS infection: in this case, the virus enters through the nose and descends very quickly into the respiratory tract. In one out of two cases it is not found in the nose, although it is already present in the bronchial and pulmonary tracts.

The question of healthy carriers also remains to be decided. Given what is known about other coronaviruses, it can be assumed that some people have an immune system capable of responding very well to 2019-nCoV. These people would have mild symptoms, which would not lead them to seek treatment. You don’t go to the doctor if you just have a runny nose! However, they would be contagious, and would spread the epidemic without knowing it.

To be able to clarify this essential point, it will be necessary to wait to obtain further information from Chinese doctors.

A Virus in The Process of Adapting to Humans

Viruses can mutate. Is there a concern that the coronavirus could become more dangerous for humans? Probably not. In fact, there are no known cases of low pathogenic coronavirus that have become highly pathogenic.

On the contrary, adaptation mechanisms generally cause highly pathogenic viruses to lose virulence over time. Thus, viruses responsible for influenza pandemics are initially relatively poorly adapted to humans. Gradually, they accumulate mutations and become less pathogenic.

It can be assumed that coronaviruses are also subject to similar mechanisms. Indeed, the only known highly pathogenic coronaviruses have emerged very recently: in 2003 for SARS and in 2012 for MERS. Conversely, studies of the genomes of low pathogenic coronaviruses have revealed that they passed into humans several decades ago, probably in the 1940s or 1950s. Unlike SARS and MERS, they have therefore had time to lose their virulence.


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10 Thyroid Eye Disease Photos (TED) – Before and After

Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change

TED is an organ-specific idiopathic autoimmune disease. It usually begins with an active inflammatory orbital phase lasting 6 to 24 months, during which extraocular muscle and orbital fat develop. This can lead to proptosis, compressive optic neuropathy (CON) and compromised extraocular muscle motility. There is an initial progressive deterioration, followed by a peak before spontaneous improvement.

  • The inflammatory phase is followed by an “inactive” fibrotic phase.
  • The inactive phase is a phase of chronic exhaustion during which further changes are unlikely. Loss of vision may occur, usually after a delay in the start of treatment.
  • Hyperthyroidism and ETD usually appear within 18 months. However, TED can also develop years before or after the onset of hyperthyroidism.
  • A small minority of patients never develop associated thyroid disease. Most patients with TED have clinical or biochemical signs of hypothyroidism, but some are euthyroid (at least at the time of presentation). Therefore, thyroid dysfunction may precede, continue or coexist with TED.

Thyroid Eye Disease (TED) -Treatment

Processing options include:

  • Prisms to control diplopia.
  • Botulinum toxin to reduce swelling of the upper eyelid.

Medical treatments:

  • Oral or systemic steroids
  • Octreotide and lanreotide
  • Ciclosporin
  • Intravenous immunoglobulin

New treatments:

  • Selenium
  • Rituximab
  • Anti-tumor necrosis factor
  • Orbital radiotherapy.

Surgical procedures:

  • Orbital decompression
  • Strabismus surgery
  • Lengthening of the lid
  • Blepharoplasty

See before and After Photos of TED Real Patients



Click ”Next” to See More Before and After Photos of TED Real Patients

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Health

Learn about symptoms of thyroid eye disease

By: Dr. Terry Davies NY, Endocrinology, Diabetes, & Metabolism

Reading Time : 7 minutes



Summary:



Thyroid Eye Disease vs Graves’ Eye Disease : Thyroid Eye Disease and Graves’ disease are NOT the same

Thyroid Eye Disease (TED) is a unique condition. But it’s often considered part of a separate disorder called Graves’ disease. Why the confusion? Well, despite their differences, the two share a number of similarities. For starters, TED goes by many names. Some people may call it “Graves’ disease eyes.”


Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


6 Commonly Used Terms for Thyroid Eye Disease (TED)

  • Graves’ ophthalmopathy (GO)
  • Thyroid-associated orbitopathy (TAO)
  • Thyroid ophthalmopathy
  • Graves’ orbitopathy
  • Graves’ eye disease
  • Graves’ disease eyes

Adding to the confusion is the fact that people with Graves’ disease often develop TED. However, a person can develop TED without having Graves’ disease.

Thyroid Eye Disease (TED) and Grave’s disease are often linked

treatment for thyroid eye disease
thyroid eye disease treatment

Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


The similarities don’t stop there. Both TED and Graves’ disease are serious autoimmune conditions, meaning the body’s immune system attacks healthy tissue.
But a key difference is that each condition affects a different part of the body. That’s why treatment for Graves’ disease won’t work for TED. And TED treatment won’t work for Graves’ disease.



Key Differences Between Thyroid Eye Disease (TED) and Graves’ disease


thyroid removal graves disease

Thyroid Eye Disease (TED)

  • Eyes

Graves’ Disease

  • Thyroid


thyroid eye disease surgery

Thyroid Eye Disease (TED)

  • The immune system causes the muscle and fat tissue behind the eye to become inflamed and swollen
  • Over time, the swelling can cause permanent changes to the eyes

Graves’ disease

  • The immune system attacks the thyroid gland
  • This causes the thyroid to become overactive, also known as hyperthyroidism
  • As a result, the body’s metabolism can speed up

thyroid eye disease hypothyroidism

Thyroid Eye Disease (TED)

  • Dry, gritty eyes
  • Eyelid redness and swelling
  • Watery, teary eyes
  • Bulging eyes
  • Light sensitivity
  • Double vision

Graves’ disease

  • Fast heartbeat
  • Irritability and anxiety
  • Tiredness
  • Too much sweating, sensitivity to temperature
  • Unhealthy weight loss

Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


TED is different than Graves’ disease and requires different treatment. Discover a Medicine that Improves TED Symptoms Like Eye Bulging, Double Vision and Pain.


Active vs Inactive Thyroid Eye Disease

Identify Thyroid Eye Disease early before lasting damage occurs

Thyroid Eye Disease (TED) changes over time. For most people, TED goes from Active to Inactive. During Active TED, your signs and symptoms will first appear. Scarring may also start behind your eye.

TED may be Active for a limited time, so an early diagnosis is important. Medicines only help while the disease is Active.

After a while, the disease will change from Active to Inactive. During Inactive TED, some changes may go away. But others may become permanent.


Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


Timeline of Thyroid Eye Disease



Healthy eye

thyroid eye disease natural treatment

Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


What’s happening behind the eye?

  • The back of the eye is free from inflammation ( redness and swelling )
  • The muscle and fat tissue do not press against the eye or on the optic nerve, allowing for normal vision

What’s happening in front of the eye?

  • The eyeball and eyelid both appear normal


Eye During Active Tyroid Eye Disease (TED)

Thyroid Eye Disease  Before and After Photos

What’s happening behind the eye?

  • Muscle and fat tissue become inflamed and swell

How long does it last?

  • The swelling makes the eye bulge forward. The swelling can cause double vision and misaligned eyes. In some cases, it can even threaten the ability to see
  • The eyelids can also be pulled back. This exposes more of the eye than normal, wich can lead to other symptoms such as dry eyes
  • Over time, scarring (also known as fibrosis) can take place, causing permanent damage to the eye

Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


what’s happening in front of the eye?

  • Visible symptoms appear, including redness, vision changes, misaligned eyes, and/or bulging eyes. Your doctor may refer to this bulging as proptosis (prop-toe-sis) or exophthalmos (ek-sof-thal-muhs)
  • 6 Months to 3 years

How is it treated?

  • Various medicines and/or medical procedures


Medicines have obly been shown to help signs and symptoms during Active TED



Eye During Inactive Thyroid Eye Disease (TED)

Approved Treatment for TED

What’s happening behind the eye?

  • Some changes, like redness, may improve
  • Other changes, such as bulging eyes (exophthalmos) or double vision (diplopia), may become permanent

How long does it last?

  • Damage from scarring may be permanent

Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


How is it treated?

  • Once TED is inactive, surgery – or multiple surgeries – may be the only option
  • Surgery can reduce how much the eyes bulge. It can also correct crossed eyes, called strabismus (struh-biz-muss)
  • Surgery can also fix changes to the eyelids and other changes affecting how the eyes and face look


Thyroid Eye Disease Risk Factors

What factors could be linked to Thyroid Eye Disease?

It’s not known why some people develop Thyroid Eye Disease (TED) and others don’t. But there are some factors that may make a person more likely to develop the condition.

Gender

Women are 5 times more likely than men to develop TED.

Age

TED occurs most often between ages 40 to 49 years and 60 to 69 years.


Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


Radioactive Iodine

Radioactive iodine, a medicine used to treat Graves’ disease, can increase the chances of getting TED and can make TED worse.

Family History

Thyroid conditions often run in families. If a family member develops a condition that affects his or her thyroid, you may be at a greater risk for developing one.

Thyroid Problems

Thyroid problems such as Graves’ disease are known risk factors for TED.

Smoking

People who smoke are up to 8 times more likely to develop TED. In addition, smoking can also make the disease more severe and may make treatment less effective.



Thyroid Eye Disease Symptoms & Signs

Recognize the top 10 symptoms and signs of Active TED, including bulging eyes

Active Thyroid Eye Disease (TED) can affect you in many ways, like how you look, see, and feel. Some changes may happen slowly, while other changes may develop quickly. Active TED affects everyone differently.

It’s important to remember that any change—no matter how big or small—needs to be taken seriously. The sooner you let your doctor know, the sooner he/she can make a difference in your care. Medicines have only been shown to help signs and symptoms during Active TED.

Below are the Top 10 signs and symptoms of Active TED to look out for.

10 symptoms and signs of Active Thyroid Eye Disease

Eyelid retraction

  • What you may notice: Your eyelid may be pulled back so that more of your eye is showing than normal. You may also find it hard to close your eyes all the way.

Swollen, puffy eyelids

  • What you may notice: Your eyelids may look red and swollen. At first, you or your doctor may think this is because of allergies or an infection. Your doctor may refer to this change as eyelid edema (ih-dee-muh).

Bulging eyes

  • What you may notice:Your eyes may bulge forward. This may happen in just one eye or both eyes. Your doctor may refer to this change as proptosis (prop-toe-sis) or exophthalmos (ek-sof-thal-muhs). During an examination, your doctor may measure the amount of eye bulging using a ruler or a special instrument called an exophthalmometer (ek-sof-thuhl-mom-i-ter).

Dry, gritty eyes

  • What you may notice: Your eyes may feel dry or sandy. It may also feel like there is something stuck in your eye.

Red, swollen eyes

  • What you may notice: Your eyes may look red or bloodshot. They may also look swollen. At first, these changes may be confused with allergies or an infection. Your doctor may refer to these changes as erythema (er-uh-thee-muh) or chemosis (key-moe-sis).

Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


Watery, teary eyes

  • What you may notice: Your eyes are too watery or you’re tearing up too much.

Eye pain, eye pressure

  • What you may notice: You may feel pain in, around, or behind your eye. You may feel pressure behind or around your eye or get headaches.

Light sensitivity

  • What you may notice: Your eyes may become extra sensitive to light. Your doctor may refer to this change as photophobia (foh-tuh-foh-bee-uh).

Blurry vision

  • What you may notice: Images may appear blurry or out of focus.

Double vision

  • What you may notice: You may see 2 images of the same object. Your doctor may refer to this change as diplopia (dih-ploh-pee-uh).


Other Thyroid Eye Disease symptoms to watch for


Misaligned eyes

Looking in the mirror, you may notice that the position of your eyes doesn’t match or they are misaligned. This can cause other changes, like double vision.

Color vision loss

You may notice colors look duller or washed out. In rare cases, you may lose all color in your vision. Losing color vision can also mean that damage is happening to your optic nerve. This only happens in about 5% of cases, but it can mean your sight is threatened. You should talk to your doctor right away if you notice color vision changes.


Vision loss

In some cases, TED can lead to blindness.


Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


Be sure to check your eyes frequently, maybe pick a day of the week. If you spot changes, speak to your doctor right away. Medicines have only been shown to help signs and symptoms during Active TED. A Doctor Discussion Guide to aid Your Conversation About TED Treatment. Find a Specialist. Speak to a Nurse Advocate.


Living With Thyroid Eye Disease

Thyroid Eye Disease affects more than your eyes. It can affect your daily life.

The true impact of Active Thyroid Eye Disease (TED) goes well beyond your eye health. It can also have a tremendous impact on nearly all aspects of life, including your mental health. While these changes may not always be visible, they’re just as real and shouldn’t be overlooked when talking to your doctor. Below are changes to daily life that you should keep track of.

Impact of TED on daily life

Physical impact

Pain and changes to your vision or how easily you can move your eyes can limit how well you do certain tasks. These can include:

  • Difficulty driving
  • Depending on others for care
  • Having to miss work because of symptoms

Emotional impact

Dealing with TED can be frustrating and you may feel embarrassed about how it changes the way you look. It’s not uncommon to experience:

  • Depressive feelings
  • Anxiety

Social impact

How you live with TED can change your social life and your relationships. For example, you may:

  • Avoid other people and social events
  • Have a hard time making normal facial expressions
  • Have problems holding face-to-face conversations

Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


Impact to sense of self

TED can change your appearance and this can have an impact on your emotions. As a result, you may feel:

  • Self conscious
  • A loss of self-worth
  • Like you don’t recognize yourself in the mirror
  • Disconnected from friends, family, and hobbies

Note all symptoms and signs of Active TED are visible. Be open and honest with your doctor about how the condition affects your daily life.


Thyroid Eye Disease Tracking

3 simple ways to keep track of Active Thyroid Eye Disease signs and symptoms

The symptoms of Active Thyroid Eye Disease (TED) can change over time. Some symptoms may change slowly and others quickly. The sooner you spot changes, the better your doctor can manage the disease. Medicines have only been shown to help signs and symptoms during Active TED, so it’s important to catch symptoms early.

Download the A.C.T.I.V.E. TED Symptom Tracker

Noticing changes in your symptoms is an important part of managing TED. Not sure what signs and symptoms to look for? Use the A.C.T.I.V.E. tool to help you keep track and discuss them with your doctor.


Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


Selfie snapshot

Something as simple as a selfie a week can help keep track of TED. Your doctor can use these photos to check if the disease is getting worse.

Below are a few tips on how to take a good selfie:

  • Make sure the area is well lit
  • Look straight at the camera
  • Zoom in on your eyes, if possible

Journal

You can download the A.C.T.I.V.E. guide or use your own journal to write down symptoms and track changes to your vision over time.


Be sure to check your eyes frequently. Pick a day of the week for a regular symptom check. If you notice any changes, let your doctor know right away.


Thyroid Eye Disease Treatment

Find an experienced Thyroid Eye Disease specialist

Thyroid Eye Disease (TED) is best treated by a team of specialists, which may be made up of an ophthalmologist who specializes in TED (often an oculoplastic surgeon) and an endocrinologist. Together, these unique doctors have the ability—and experience—to manage your TED and guide you through the different issues and concerns you may face.


Remember, your insurance plan may require a referral from your primary care physician before you can see a specialist. Before you make an appointment, be sure to check the details of your insurance plan.


Take a closer look at your partners-in-care

eye drops for graves disease

Ophthalmologists and oculoplastic surgeons who specialize in TED

One of these eye specialists may be the first doctor you see specifically to diagnose and treat your TED. When it comes to your care, ophthalmologists and oculoplastic surgeons do a number of things, such as:

  • Conduct a comprehensive baseline eye exam and evaluate how your TED is changing over time
  • Determine whether you have Active or Inactive TED
  • Develop a treatment plan Decide how often your condition needs to be checked
  • Work with your other doctors to help manage your TED

Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


thyroid eye disease nhs

Endocrinologists with a deep understanding of TED

Your endocrinologist specializes in glands and their hormones, like the thyroid and the important hormones your thyroid makes. Here are a few things you can expect your endocrinologist to do:

  • Help you manage Graves’ disease if you’re diagnosed with it
  • Discuss the risk of developing TED, and the importance of seeking treatment during Active TED
  • Refer you to an ophthalmologist or an oculoplastic surgeon for a baseline eye exam


Manage Your Thyroid Eye Disease

Tips for discussing Thyroid Eye Disease with your doctor

Thyroid Eye Disease (TED) is a complex disease with unique treatment needs. That’s why it’s so important that you get the right care from the start.

Be your own best advocate

Once you’ve found a doctor, or team of doctors, who specialize in TED, below are some tips to get the most from every appointment with them.

After all, TED is a time-sensitive condition. Medicines have only been shown to help signs and symptoms during Active TED.

At your next doctor’s visit, use the tips below to ensure you voice is being heard, and you’re getting the care you need.


Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


If you are experiencing eye symptoms or are at risk for TED, find a TED specialist today and request a baseline eye exam. FDA-Approved Medicine.


See a Thyroid Eye Disease (TED) Specialist
Get Expert Care

TED is a unique and rare condition. Make sure you’re seeing
a doctor who has experience treating it.

Just type: ” Find a specialist in Thyroid Eye Disease (TED) near you


Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change



Self-advocacy tips for Thyroid Eye Disease

Don’t downplay your symptoms

You may feel reluctant to share with your doctor how TED really makes you feel.

But remember, every little bit of information helps your doctor decide the best way to manage your TED.

Keep track of your symptoms

TED can change over time. The symptoms you experience can get worse or better, and you may have new symptoms develop over time.

Every change is important and keeping track of it all can help your doctor better manage your care.

Be specific

When describing your symptoms, be sure to:

  • Use descriptive language: “I’m very sensitive to light. Even a small amount of light hurts my eyes.”
  • List out the ways it has affected your daily life: “I’m not able to drive anymore.”
  • Identify how long it’s been bothering you: “I first noticed light hurting my eyes about 2 weeks ago.”

Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change


Ask questions

If you have questions about your TED, don’t be afraid to ask. Be sure to write down a list of questions to ask before going to your appointment.

These questions can help get the conversation going:

  • What specific changes should I look out for when trying to spot TED?
  • How often should I schedule appointments for my TED?
  • How TED is treated?

Take notes

Taking detailed notes during your doctor’s visit is an important way to stay up-to-date about your condition. On appointment days, be sure to bring a pad and pen with you.

If you find it difficult to take notes and listen at the same time, ask your doctor if you can record your conversation. That way, you can focus on what they have to say and take notes later.

Bring a friend or loved one along

Doctor’s appointments can be emotional. A friend or loved one sitting next to you during an appointment can help put you at ease.

And since they’ll be in the room with you, they can also help you by taking notes during the appointment.



Thyroid Eye Disease and Vision Support Groups

Taking on Thyroid Eye Disease, together

If you have Thyroid Eye Disease (TED), know you aren’t alone. Hearing how others cope with TED can be help you learn to manage it or just help you feel better.

Here are some organizations and communities dedicated to helping those with TED and vision problems connect with each other and get support:


hyperthyroidism eyes

The American Thyroid Association® (ATA) is a professional medical association dedicated to transforming thyroid care through clinical excellence, education, scientific discovery, and advocacy in a collaborative community. The ATA patient resource pages provide up-to-date information for thyroid patients, their families, and other interested public communities.


thyroid eye disease icd 10

VisionAware™ helps adults who are losing their sight continue to live full and independent lives by providing timely information, step-by-step daily living techniques, a directory of national and local services, and a supportive online community. Learn more >


protrusion of an eyeball

With nearly 100 years of service, American Foundation® for the Blind (AFB) is a public policy and research center for the advancement of accessibility and disability-inclusion causes. The AFB advocates for better policies that promote equality and opportunity for people who are blind or visually impaired to create a culture of inclusion at work, at school, and in communities. Learn more >


can hypothyroidism cause dry eyes

Thyroid Change™ is a collaborative network and health information website created to unite an international community of medical professionals and patients under the same innovative vision: personalizing thyroid care for optimal wellness. Learn more >


itchy eyes thyroid

The Job Accommodation Network (JAN) is the leading source of free, expert, and confidential guidance on workplace accommodations and disability employment issues. Their resources include fact sheets on job accommodations available for those affected with Graves’ disease and low vision. Learn more about accommodations for people with low vision > , Learn more about accommodations for people with Graves’ disease >


best eye drops for graves disease

Lighthouse Guild is dedicated to addressing and preventing vision loss. The Lighthouse Guild helps coordinate care for eye health, vision rehabilitation, behavioral health, and related services to reduce the burden of living with vision loss. Learn more >


exophthalmos in graves disease

The Hormone Health Network® is the nation’s endocrine patient education resource. They are committed to helping patients have more informed discussions with their doctors about hormone health, disease, and treatment. Learn more >


large eyes thyroid

Founded in 1908, Prevent Blindness® has become the nation’s leading volunteer eye health and safety organization dedicated to fighting blindness and saving sight. Focused on promoting a continuum of vision care, Prevent Blindness offers resources to those affected by vision issues. Learn more >


eye drops for graves disease

National Federation of the Blind (NFB) is the oldest and largest nationwide organization for Americans with blindness. The NFB coordinates many programs, services, and resources to provide information and support to children and adults with blindness. They also have a comprehensive network of programs and services for the visually impaired community. Learn more >


TED Treatment. Information For Patients

Listen to Your Eyes is a community resource for people living with or caring for someone with TED. This page offers resources, tips, support, and more. You’re not alone living with TED. Listen to Your Eyes is a place where you can come to learn about TED and be inspired by others who are navigating their own TED journeys as patients and caregivers.

Learn more >


eye signs in hyperthyroidism

oneGRAVESvoice is an online educational resource and social forum for the Graves’ disease and Thyroid Eye Disease (TED) communities. People living with or impacted by TED can:

  • Access and learn about TED-related topics through a variety of sources (news, articles, and videos)
  • Find support by connecting with other patients and community members via a social wall
  • Ask questions about symptoms, diagnosis, and treatments

The TED Educator page provides relevant articles and videos to help patients understand and manage TED. Specifically:

  • Clinical presentation: an overview of the signs and symptoms and what to look for in diagnosing TED Learn more >
  • Getting a diagnosis: resources to explain the process of a TED diagnosis and what it means for you and your doctor Learn more >
  • Associated diagnosis: examples of how TED is related to autoimmune deficiencies such as Graves’ disease Learn more >
  • Post-diagnosis resources: provides patients with information to help manage a diagnosis of TED, including physicians, centers of excellence, and treatments Learn more >


hyperthyroidism protruding eyes

Established in 1990 as the National Graves’ Disease Foundation, the Graves’ Disease & Thyroid Foundation provides education and support for patients, family members, caregivers, friends, and healthcare professionals.

Learn more >


dysthyroid ophthalmopathy

The SER 4 Thyroid Group is a group of advocates who provide support, education, and resources for patients and family members affected by Graves’ disease, thyroid eye disease, and hypothyroidism.

Learn more >


The American Association of Clinical Endocrinologists (AACE) is a professional community of physicians specializing in endocrinology, diabetes, and metabolism committed to enhancing the ability of its members to provide the highest quality of patient care. The AACE’s Up To Here campaign provides you with resources to keep you informed and proactive about your thyroid health.

Learn more >


disease where your eyes pop out

Thyroid Federation International is a global network of patient-focused thyroid disorder organizations. The goal of the federation is to improve the lives of those affected by thyroid disorders around the world.

Learn more >


hashimoto's thyroiditis eye

The American Academy of Ophthalmology is the world’s largest association of eye physicians and surgeons. A global community of 32,000 medical doctors, with a mission to protect sight and empower lives by serving as an advocate for patients and the public, leading ophthalmic education, and advancing the profession of ophthalmology. Learn more >


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Read More: Thyroid Eye Disease Photos (TED) – Unbelievable Before and After Pictures! See How Patients Look Different and Totally Change

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Health

Lyme Disease – All you Need to know

Lyme Borreliosis, more commonly known as Lyme disease, is a bacterial infection that can be transmitted to humans through tick bites. This infection is widespread throughout the world and there are a few thousand cases per year in France. When left untreated, the disease can take several years to develop. Researchers speak of an emerging disease, as the number of cases is increasing.

Symptoms of Lyme Disease

Tick bites most commonly occur in the lower limbs. It can also occur on the child’s face. The disease progresses in three phases, the duration of which can vary greatly from one individual to another. The symptoms of Lyme disease are therefore numerous and spread over several phases.

In addition, the periods between phases may be asymptomatic from one individual to another. Nevertheless, several symptoms will help you detect the presence of this infection.

First Phase of the Disease

The skin lesion represents the so-called primary phase of Lyme disease. You should be able to visually diagnose the infection since the most common features appear on the skin. A more or less red spot, very similar to a mosquito bite, should appear very quickly on your skin. The bite of a tick, however, evolves over time, since after 3 days, this spot can spread and have a diameter of two centimetres.

After a month, the bite will continue to grow and should reach 10 centimetres in diameter. In some cases, it can even exceed 45 centimetres in diameter. This spot, called chronic erythema (or ECM), does not itch and always progresses centrifugally. The ECM may sometimes be surrounded by a red ring. Be careful, inflammation may be present if this area is hot.

During this first phase, you may notice some :

  • Headaches;
  • Fever flare-ups;
  • Chills;
  • Joint and muscle pain.

It should be noted that 20% of people affected by this disease, the ECM remains very discreet, disappears after a month and the individual will not have noticed its presence. Lyme disease will go totally unnoticed and no treatment will have been taken. These cases can be serious, since the disease may become more complicated during the second phase.

Second Phase of the Disease

The second stage of Lyme disease may occur a few weeks or even months after the first stage, when a tick bite is given and no treatment has been taken by the individual. This second phase can be defined by several points as dizziness associated with general fatigue. But it is important to watch the following points:

  • An appearance, as in the first phase, of skin lesions, or red blotches;
  • Pain in the joints will begin to appear, with arthritis in the large joints such as knees, shoulders, elbows, etc. ;
  • Neurological disorders, meningitis, even facial paralysis;
  • Cardiac disorders in some cases, syncopations, palpitations, etc. have already been observed.

It becomes essential to treat the disease, otherwise the third phase could develop, years later for some individuals, in conditions that can be very serious.

Third Phase of the Disease

If Lyme disease has not been treated in the first two phases, the third phase could prove fatal to the infected individual. All of the above symptoms will slowly worsen, becoming chronic, during this last phase, which can occur years after infection.

All organs may be infected and will spread to nerves, eyes, joints, and even the heart and spleen. In addition, atrophy of skin patches may be observed. The skin will become very thin, even transparent and will give a crumpled paper effect with a reddish-violet tinge. The cardiac consequences can also be serious depending on the infection.

It should be noted that the evolution towards this third phase remains extremely rare, even if the individual has not taken any treatment.

Causes, Transmissions and Recommendations

Lyme disease is transmitted through the bite of ticks. It is transmissible in humans but also in many animals. There are a very large number of forms of the Borrelia bacteria.

Unfortunately, there is no real way to avoid being bitten outside of places where ticks might be present, such as forests etc. In addition, their presence and the incidence of infection may vary depending on where you are.

The only solution therefore remains to be vigilant. When working in the wilderness, or taking your Sunday walk in the forest, try to favour long clothing for example. Ticks generally attack the lower limbs, so pants should be sufficient. Beware of children, who can be bitten on the upper limbs. You will therefore have to be very careful. Once your activity is over, it is strongly advised to inspect yourself meticulously to see if a tick has hooked on. They are fairly simple to identify with their four pairs of legs and their eyeless head. The tick’s swollen belly means that it has stung you, since it has started to drink your blood.

Do not try to remove it by scratching. We advise you to use tweezers as close to the skin as possible and avoid the ether. Once the tick has been removed, disinfect the area.

How is it Diagnosed?

As we have seen above, it is very difficult to diagnose Lyme disease. Symptoms can be very numerous but can also be painless or even almost “invisible”. In addition, it is very easy to confuse the symptoms described with other diseases. When you notice these symptoms, it is advisable to go to the doctor quickly and tell him or her if you have been bitten by a tick. When the individual does not know if he or she has been bitten by a tick, he or she will be able to tell the doctor if he or she has been in places that are likely to contain ticks; for example, during walks in the forest. It should be noted that blood tests do not always validate the presence of the infection, especially if the patient is still in the early stage of the disease. The doctor may also perform an electrocardiogram to check for possible atrioventricular disorders. In these cases, the patient will have to be hospitalized.

In advanced cases of Lyme disease, i.e. from the second stage onwards, neurological examinations will be necessary. They will reveal a decrease in sensations, muscular strength and possible nerve inflammation.

Treatment of Lyme Disease

Antibiotics are mandatory to treat the infection caused by ticks. These antibiotics will completely eliminate the presence of Borrelia bacteria anywhere in the body. The complications of Lyme disease can be multiple.

However, depending on the time since the infection, and therefore the phase of the disease, the treatment and dosage may be completely different. Antibiotics should be taken for a minimum of two weeks and up to three weeks depending on the areas affected by the infection. The symptoms should therefore begin to disappear and any complications can be avoided.

In the most advanced cases of the disease, class 3 antibiotics should be prescribed by the doctor. These drugs will have to be taken intravenously over a period of time that can be much longer. In cases of hospitalization, a corticoid is often administered. Fortunately, most of the symptoms can be eradicated.

Possible Complications

Complications towards the third phase are extremely rare, but they do occur. It is therefore important to consult a doctor immediately if you think you have been bitten by a tick. In addition, not all of the symptoms described above will always disappear completely. Treatment for Lyme disease will therefore have to be taken to try to alleviate the symptoms that have become chronic.

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The Mysteries of the Thyroid: The 8 Symptoms That Can Reveal a Thyroid Problem

By Dr Jacques Amselem – General practitioner


Many people suffer from thyroid dysfunction. It is often a specific symptom that prompts patients to consult their doctor. Dr. Jacques Amselem, a general practitioner, reminds us of the signs that should alert us.

What is the thyroid?

The thyroid is a butterfly-shaped gland, located at the base of the neck, which produces hormones necessary for the regulation of the whole body. A malfunction can cause many inconveniences on general health. For example, when the thyroid gland produces too many hormones it is called hyperthyroidism, often associated with autoimmune Basedow’s disease.

Conversely, when the gland slows down, the patient suffers from hypothyroidism. Often, alerted by certain signs, patients consult their general practitioner. The latter will then prescribe, depending on the case, a blood test with thyroid hormone dosage, an ultrasound or a scintigraphy.

Extreme Fatigue, a Sign of Hypothyroidism

General fatigue is often the first sign of hypothyroidism. This is because the lack of hormones causes the body to function in slow motion. The patient then suffers from sleep disorders and muscle fatigue. This tiredness is also accompanied by concentration and memory problems.

Weight Fluctuations

Thyroid dysfunction often leads to weight fluctuations. In the case of hyperthyroidism, patients often experience weight loss while eating normally. Conversely, those with hypothyroidism often report weight gain, even though they do not eat more.

Problems With Temperature Regulation

The thyroid also controls body temperature. Hypothyroidism is manifested by coldness and lower temperatures on the extremities (toes, nose, etc.).

Conversely, hyperthyroid people often feel too hot, sweat with the slightest effort and complain of sweaty hands.

A Skin and Sander Modification

In hypothyroidism patients experience dry skin, hair falling out and fingernails turning.
Mood disorders, a sign to be taken into account

Nervousness, anxiety, persistent depression for no apparent reason or emotional instability are also signs of thyroid dysfunction.

An Accelerating Heart Rate

An increased or decreased heart rate may be a sign of thyroid problems. In detail, a slower heart rate is a sign of hypothyroidism, while a faster heart rate is often a sign of hyperthyroidism.

Transit Problems

Among the symptoms of hypothyroidism, the lack of hormones can manifest itself as constipation or bloating. Conversely, hyperthyroidism can cause diarrhea.

A Palpated Nodule

If you notice a small lump in your thyroid gland, whether painful or not, you should consult a doctor. The doctor will look for clinical signs of a thyroid disorder and will prescribe additional tests.

If you think you have a hypothyroid or hyperthyroid profile, you should first talk to your doctor (GP, gynaecologist, endocrinologist), as the symptoms of thyroid dysfunction can vary from person to person and may also be an expression of other diseases. A complete check-up will allow you to know for sure and, if necessary, to undertake an appropriate treatment.

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Weight and Diabetes: Dangerous Connections!

By Pr. Michel  Pinget

Head of the Endocrinology Department of Strasbourg University Hospital


Being overweight and diabetes are intimately linked. Three-quarters of type 2 diabetics are obese. What are the causal links between these two diseases? What influence do diabetes treatments have on kilos? Can new drugs act on both levels? Answers to your questions.

Diabetes and obesity are two major epidemics on the march around the world. The fact is simple: there are 400 million obese adults on Earth, and there will be more than 700 million by 2025. Obesity could become the leading cause of death in the USA in the near future.
As for diabetes, there are 246 million diabetics in the world. Every year, 7 million people develop diabetes, that is two every second! There will be 380 million in 2025. While the number of cases is increasing in Europe and America, there is a real explosion in China and India. Diabetes doubles the risk of death and is responsible for 3 million deaths and 1 million amputations.

Obesity and Diabetes: Strongly Linked Diseases

If the epidemics of diabetes and obesity seem to follow the same progression, it is not by chance: these two diseases are so closely linked that we often speak of an epidemic of “diabetes”.
First of all, a distinction must be made between diabetes types 1 and 2: it is the latter, which accounts for 90% of diabetics, which is directly linked to being overweight. “While not all obese people become diabetics, conversely, three-quarters of diabetic patients are obese,” emphasises Prof. Michel Pinget, head of the endocrinology department at Strasbourg University Hospital.

Obesity and Diabetes: Common Causes?

So how can we explain these links between the two diseases? The observation is simple: 90% of type 2 diabetes appears after weight gain. But as Prof. Pinget points out: “Being overweight alone is not enough to cause the disease. If you are not predisposed, even if you weigh 200 kg, you will never get diabetes”.
It is therefore necessary to have a prior genetic terrain, which will lead to diabetes in the event of an unbalanced diet and significant weight gain. In this case, it is the mechanism at the origin of diabetes that is directly linked to kilos: insulin resistance. Because before real diabetes appears, the disease develops insidiously, with a progressive resistance to the action of insulin (a hormone that reduces the level of sugar in the blood and stores it). The body is forced to produce more and more of it, until it is no longer sufficient, and that is diabetes.
The causes of insulin resistance are: ageing (including age-related muscle wasting); fatty and sweet foods; sedentary lifestyles; and urbanisation and stress. The observation is therefore simple: two of the four causes of insulin resistance are common to obesity: diet and sedentary lifestyle.

Treating overweight to cure diabetes

When diabetes is managed, treatment should prevent complications, especially cardiovascular complications. This is based on various factors: control of glycemia, cholesterol and blood pressure (70% of diabetics are hypertensive). But above all, the diabetic must lose 10% of his weight and must practice regular physical activity. Overweight greatly increases the risk of complications.
“The problem is that 80% of patients who are told to eat better and exercise do not follow their recommendations,” says Prof. Pinget.
The problem is that 80% of patients who are told to eat better and exercise do not follow their recommendations,” says Prof. Pinget, which means that patients must be put on oral antidiabetic drugs and then on insulin.

Anti-Diabetic Treatments That Promote Weight Gain

In addition to diet and physical activity, type 2 diabetics can be put on treatment (oral antidiabetic drugs or insulin). However, there is a real paradox, as Prof. Pinget points out: “The better you treat diabetes, the more you control blood sugar levels, and the more people gain weight”! This phenomenon is notably linked to a better glycemic balance: no more sugar is lost in the urine…but the calories are better stored, and we regain a few kilos… This is particularly true for oral antidiabetic drugs (except for Metformin, which has a “fat-burning” effect).
But when patients switch to insulin, they also gain a few kilos (5 on average in the first year). In fact, weight gain on insulin is the second most important concern for patients, after the fear of hypoglycemia. There are many reasons for this weight gain:

  • A “defensive” food intake, to avoid the hypoglycemia that can occur with insulin injections;
  • An effect of insulin on the central nervous system;
  • An anabolic effect of insulin, which promotes fat storage.

This weight gain under treatment can have a deleterious effect in patients who are already overweight or obese, in particular by making it more difficult to achieve the goals set. And this may reduce compliance…
However, it should be noted that not all insulins have the same effect, and the most recent ones do not have the same impact on weight. In particular, the insulin Detemir (Levemir ®) leads to less weight gain in diabetics.

Anti-diabetic and anti-kilos treatments

Today, treatments have targeted actions on both overweight and diabetes.
One example is Xenical, which the Xendos study has shown to be able to help lose weight while reducing the incidence of diabetes.
And today, a new drug still being tested seems particularly effective against both diabetes and obesity: Novo-Nordisk’s Liraglutide, which acts on both insulin production and appetite. Not only does it reduce blood sugar levels, but it also causes weight loss. In trials on patients with a body mass index of 35 (often more than 100 kg), an average of 7 kg was lost: 75% lost more than 5% of their weight, 25% even lost more than 10%.
It will be necessary to wait for further trials to see if this new treatment keeps all its promises.

But whatever the treatment, the recommendation to eat a more balanced diet remains essential. And physical activity is also a must to help control both weight and blood sugar levels.
Whether you are overweight or not, whether you are diabetic or not, eating and being active remain the keys to health. Because it’s never too late to do the right thing…

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What is The Incubation Period of Coronavirus?

The incubation period of the new coronavirus in China, respectively from exposure to the onset of disease symptoms, is on average 5.2 days, but varies considerably from patient to patient, shows one of the largest studies on this epidemic.

While acknowledging that the estimate is “inaccurate”, the Chinese researchers conducting the study, published in the New England Journal of Medicine, said they based their conclusions on medical observations made for 14 days in people exposed to the virus.

The World Health Organization announced Monday that the incubation period for the coronavirus infection, which has symptoms of fever, cough and respiratory problems, ranges from two to 10 days.

Researchers studied the first 425 patients diagnosed with the virus to establish two other key characteristics of the epidemic. Since the first outbreak in Wuhan in December, the number of patients has doubled every 7.4 days.

In addition, the researchers estimate that each patient infected an average of 2.2 people.

The figure does not predict the size of the epidemic, but it is useful, as researchers believe it is small, close to the size of an influenza season (1.3) and comparable to that of the 2002-2003 acute respiratory syndrome (SARS) epidemic.

Researchers also found that human-to-human transmission has been occurring since mid-December 2019.

The results of the new study are similar to those of a team of researchers in the Netherlands, who found that the incubation period is 5.8 days, with wide variations.

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How to Protect Yourself Against Coronavirus

By Tom Moorcroft | 
Osteopathic Physician Specializing in Infectious Diseases
.


While respiratory coronavirus disease is spreading rapidly in its country of origin, China, fear is also spreading rapidly on the web and social networks. With five confirmed cases of coronavirus in the United States (as of Tuesday, January 28), we wanted to investigate the likelihood of Americans – especially those who have not recently travelled to China – getting the new coronavirus strain, 2019 Novel Coronavirus (2019 -nCoV).

With the help of Dr. Tom Moorcroft, an osteopathic physician specializing in infectious diseases, we discuss the current risk of becoming infected with the coronavirus, how to protect oneself and how to stay informed.

What is the Likelihood of Getting Coronavirus?

Right now, the risk is low for Americans, Moorcroft told CNET. “We don’t want to be blown away by this and not worry,” he said, “but there’s no need for mass hysteria because the risk is so low right now.

As of January 28, there were only five confirmed cases of coronavirus in the United States, California, Washington, Illinois and Arizona. All had recently travelled to Wuhan, China, the source of the outbreak, and all were hospitalized.

Robert Redfield, director of the Centers for Disease Control and Prevention, tweeted that the risk of coronavirus in the United States is low and that nCoV 2019 is not spreading in the United States at this time.

“Five controlled cases relative to the U.S. population are really not a threat,” says Moorcroft. “Even if you represented the 70 or so cases that are still outstanding, overall there are a small number.” At the time of writing, there were 92 cases in the United States at the moment. Moorcroft has given its opinion when that number was lower.

We understand that people may be worried about the new #coronavirus. In today’s connected world, an outbreak anywhere can be a risk everywhere. The risk depends on exposure. 2019-nCoV is not spreading in the United States at this time. The CDC continues to believe that the risk to the American public is now low.

– Dr. Robert R. Redfield (@CDCDirector) January 27, 2020

Should the Americans be concerned about the coronavirus?

According to Moorcroft, “it’s not something you should be losing sleep over right now.”

There’s no confirmed human-to-human transmission in the US, and the CDC and the World Health Organisation are working hard to make sure it stays that way. Investigative and protective efforts are fully in effect, from airport entry controls and travel restrictions to patient isolation.

Combined with Wuhan’s quarantine of its nearly 11 million citizens, the risk to the people of the United States remains low.

“Don’t roll the dice just because you live in the United States,” Moorcroft said. “Could [coronavirus] spread here? Yes, absolutely. Be aware. But right now there are only five confirmed cases in the US and we have contagious control here.”

How do You Protect Yourself From Coronavirus

For now, stick to the basics,” says Moorcroft.

The corona virus is spread by breathing in vapour, for example when someone sneezes or coughs into the air around you. Influenza and common cold viruses are also spread this way.

“What you need to do to protect yourself from coronavirus is something you need to do every day,” he says. “The only thing you can do to prevent respiratory illness is to practice good personal hygiene.”

Moorcroft also reiterates the CDC’s advice to avoid coronavirus (and other respiratory illnesses):

  • Wash your hands with soap or use an alcohol-based hand sanitizer.
  • Sneeze and cough into tissues or into your elbow. If you get snot or spit on your skin, clean it up immediately. Avoid touching your face with unwashed hands.
  • Avoid close contact with sick people, especially those with breathing problems and fever.
  • Stay home when you are sick.
  • Regularly and thoroughly clean surfaces, e.g. counters and door handles with disinfectant.

Again, all basic protection should be normal, everyday things. Moorcroft believes that additional protection, such as wearing medical masks, is not really necessary at this time, unless you have the virus or are tested for it.

“I’m travelling to LA this weekend and I haven’t even thought about wearing a mask,” he says. “As long as people don’t sneeze, cough or otherwise put their respiratory secretions on you, you should be fine.”

In addition to basic disease prevention, Moorcroft says the best (and only real) defence against disease is a strong immune system. Your body is better able to fight off disease when your immune system is booming,” he says, “and everyone should try to get them back into shape. That means getting enough sleep at night, staying hydrated, minimizing over-processed foods and getting enough micronutrients in your diet.

How can I protect myself when travelling?

The CDC has advised everyone to avoid non-essential travel to China, and Chinese authorities have closed travel to and from Wuhan and other cities in Hubei province.

If you must travel to China, the CDC encourages you to talk to your doctor first, avoid others who are ill, and avoid animals and animal markets.

If you are traveling anywhere, you should practice basic hygiene that can help you get sick on the plane.

Stay informed

Although the risk is low at the moment, Moorcroft encourages everyone to stay armed with facts. You should not ignore or ignore the virus just because you live in the United States, but do not become overly stressed or worried about it.

And if you really want to know what’s going on, Moorcroft recommends monitoring the CDC Web site, where officials post regular updates on coronavirus events. It’s easy to get carried away by the ever-increasing amount of information available online, as well as the fear factor of social media, and the best way is to get your information from the actual health organizations that are investigating the problem first.

“I hope people will feel empowered by knowing the facts,” says Moorcroft, “and say: ‘I have access to information, I know how to take care of my body and I can stay safe.

The information contained in this article is for educational and informational purposes only and is not intended as medical or health advice. Always consult a physician or other qualified health care professional with any questions you may have regarding a medical condition or health purpose.

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Should I Wear a Mask to Protect Myself From the Coronavirus?

By  Susy Hota  | 
An infection disease specialist at the University Health Network


In Wuhan, where the disease emerged last month, authorities have forced residents to wear masks covering their nose and mouth in public places. Regular and thorough hand washing is still the most effective.

How to effectively protect yourself from the new 2019-nCoV virus? The question is of concern to health authorities worldwide, who are powerless to deal with this still poorly known coronavirus, whose death toll, on Friday 24 January, was 830 cases and 26 deaths. In Wuhan, China’s eighth-largest city, where the disease emerged in December, residents are forced to wear masks covering their nose and mouth in public places, reports CNN.

So, are these devices really effective in preventing infection?

Can Surgical Masks Be Effective?

Authorities believe that these masks can help patients limit the transmission of the coronavirus. The World Health Organization recommends covering the mouth and nose when coughing and sneezing to prevent the spread of the infection. In France, the Ministry of Foreign Affairs invites travellers who have visited Asia and who must come into contact with other people to wear a surgical mask “in case of symptoms of respiratory infection (fever, cough, breathing difficulties)”. This recommendation is explained by the fact that coronavirus 2019-nCoV pneumonia “is transmitted by sputum (sneezing, coughing),” as the Ministry of Health reminds us.

Questioned by HuffPost, Sandrine Belouzard, a CNRS researcher at the Lille Centre for Infection and Immunity, believes that “wearing a mask plays an obvious barrier role”, especially to avoid “excretion [i.e. the release of virus from the body]. However, the specialist warns that surgical masks “cannot be 100% effective”. Because they are not sealed to the face (fortunately), these masks leave gaps around the mouth and do not filter all the air that is breathed in and out.

In Which Cases Are They Useless (or even worse)?

There is no need to equip yourself if you are in great shape, says the Ministry of Health. On its website, the ministry states “that the wearing of this type of mask by the non-ill population in order to avoid catching the disease is not recommended”, and that “its effectiveness has not been proven”.

These accessories could even prove counterproductive. “We are concerned that people may feel they are better protected by the mask than they really are,” Julie Vaishampayan, a physician and chair of the Public Health Committee of the American Society of Infectious Diseases, told the New York Times. Most people put their hand under the mask to scratch their face or rub their nose,” says Amesh Adalja, a specialist in infectious diseases at the Johns Hopkins University Health Security Center in Baltimore, USA, who was also interviewed by the daily. This can bring the mask wearer into contact with contaminating agents and take away from the object all its interest.

A specialist in infectious diseases at the University of Toronto, Susy Hota even recommends not wearing this type of mask, so as not to fuel psychosis in the population. “It makes people nervous [around you] and there’s no evidence that it protects you,” she told Radio-Canada.

What Precautions Should Be Taken?

It’s not spectacular, but the best way to prevent infection by the 2019-nCoV virus is to behave as “every cold or flu season,” Dr. John Wiesman, head of health issues in Washington state, where the first U.S. case of coronavirus was reported, told CNN. “As with the seasonal flu episode, the ‘barrier measures’ are effective,” the Health Department says. Here are a few rules: cough into your elbow (not your hand), use disposable tissues, and above all wash your hands regularly and thoroughly.

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Cervical Cancer: Symptoms, Screening, Treatment

By: Dr. Jean C., Pharmacist


Cervical cancer is the development of a malignant tumour of the lining of the cervix. It is considered a slowly progressing tumour disease of infectious origin. In the majority of cases, cervical cancer occurs after prolonged exposure to human papillomavirus (HPV).

This is because the long-term presence of the virus in the mucous membrane has a deleterious effect on healthy cells that can develop into cancer cells. It is the proliferation of these cancerous cells, which are initially few in number, that leads to the appearance of a more or less organised mass known as a tumour.
Since tumours appear in the mucous membrane, they are also called squamous cell carcinomas and account for almost 85% of cervical cancer cases.

Frequency

In 2015, nearly 2,797 new women were newly diagnosed with cervical cancer. This low annual number of new cases makes it the 12th most common cancer in women. This cancer is, on average, diagnosed at the age of 51 and was responsible for 1,092 deaths in 2015 in France. It is a cancer qualified as having a good prognosis, as its 5-year survival rate is 67%, i.e. 67% of cervical cancer patients are alive 5 years after diagnosis. Improved screening through regular cervical smear testing (UTC) has almost halved both the number of new cases and the number of cervical cancer-related deaths. It is estimated that with optimal screening, the number of cervical cancers could be reduced by almost 90%.

Risk Factors

Having one or more risk factors does not necessarily lead to the development of cancer. They increase the likelihood of developing cancer compared to an unexposed person. However, a cancer can develop without any risk factors being present.

Namely! A risk factor is an element that can promote the development of cancer.

Human Papillomavirus (HPV)

It is the main inducer of cervical cancer. Indeed, a prolonged infection of 10 to 15 years by the human papillomavirus is responsible for nearly 70% of cervical tumours.

HPV is transmitted by contact with the skin and mucous membranes, most often during sexual intercourse. Infection with this virus is very common and mostly cures spontaneously. However, in 10% of cases, the virus persists in the lining of the cervix, which can lead to precancerous lesions that can develop into cancer.

To know! There are more than 80 strains of papillomavirus and only a small number of them cause cervical cancer.

Since 2007, there are two vaccines against HPV types 16 and 18. It is a very good means of prevention for this type of cancer, but it does not replace gynaecological monitoring.
Other risk factors

A scientific link has been established between factors other than HPV and the development of cervical cancer:

  • Early sexual debut;
  • Multiple sexual partners: The more different partners you have, the greater the chance of being exposed to HPV, and therefore the greater the risk of developing cancer;
  • Tobacco;
  • HIV infection (AIDS) or taking an immunosuppressive treatment: because in both cases our immune system is less efficient, which leads to a loss of efficiency in the fight against HPV viruses.
  • Having several children ;
  • Taking birth control pills;
  • Sexually transmitted diseases: such as genital herpes and Chlamydia.

Precancerous Lesions of the Cervix

Precancerous lesions are changes in the cells of the epithelium of the cervical mucosa (cells covering the mucosa) that are not yet cancerous, i.e. the tissue is abnormal but not yet cancerous. The precancerous lesion is not designated as a cancer because it does not have all the criteria for malignancy of a cancer. These disorders are most often caused by the long-term presence of the human papillomavirus (HPV) in the cervix. The viral infection leads to cellular suffering that reflects the evolution of the tissue into cervical cancer. Precancerous lesions may spontaneously regress or progress to cancer.

Precancerous lesions are also called cervical intraepithelial neoplasia or CIN. They exist in more or less severe forms. A classification allows us to distinguish three main types of lesions according to their severity:

  • CIN 1: the abnormal cells affect 1/3 of the thickness of the epithelium;
  • CIN2: the abnormal cells affect 2/3 of the thickness of the epithelium;
  • CIN3: the abnormal cells affect the entire epithelium.

Depending on the grade of precancerous lesion, there is a probability of progression to higher grade CIN, cervical cancer or spontaneous regression.

Probabilities of regression, persistence and progression of CIN (Ostor, 1993)

LesionsRegressionPersistenceProgression to higher CIN Progression to invasive cancer
CIN1
57%
32%
11%
1%
CIN2
43%
35%
22%
5%
CIN3
32%
56%

>12

We can retain from this table that:

Low-grade precancerous lesions (CIN 1) are more likely to regress than to progress to a higher grade. The higher the CIN, the greater the risk of progression to cancer and the more limited the likelihood of spontaneous regression.

The evolution of these precancerous lesions into cancer is a slow, progressive phenomenon that can be demonstrated by a cervico uterine smear (UCS). It is therefore possible to identify and treat them before they become cervical cancers.

Screening

Because of its slow progression and the presence of curable precancerous lesions, cervical cancer can be detected at an early stage, and can even be completely prevented by detecting precancerous lesions.

Screening is mainly based on a cervical smear, which is a collection of cells from the surface of the cervix that are then analysed using a microscope. The appearance of the cells as well as the organization of the tissue allows biologists to observe possible precancerous lesions or the presence of cervical cancer.

To know! It is recommended every three years, after 2 normal smears spaced one year apart for all women aged 25 to 65.

Symptoms

Cervical cancer often develops without causing any particular symptoms, especially at an early stage. This is why it is essential to have a gynaecological follow-up with cervico uterine smears in order to detect it as early as possible.

There is also a set of symptoms that are not specific to cervical cancer, but whose persistence or intensity may suggest a tumour:

  • Induced metrorrhagia: which is low grade bleeding caused by sexual intercourse;
  • Spontaneous metrorrhagia: Bleeding that occurs without apparent cause;
  • Pain during intercourse;
  • White vaginal discharge;
  • Pain in the lower abdomen with difficulty in urinating, a continual urge to have a bowel movement;
  • Lower back pain.

These symptoms can be found in the disease other than cervical cancer, but it is important to report them to your doctor so that he or she can determine their origin.

Diagnosis

The diagnostic work-up for cervical cancer begins after an abnormal screening test or the appearance of suggestive symptoms. Complementary examinations are then set up with the aim of :

  • Confirm the diagnosis of cancer and define the type of cells involved.
  • Determine the stage of the disease in order to propose an appropriate treatment.
  • Identify possible contraindications to certain treatments

Definitive confirmation of the diagnosis of cervical cancer is only possible after analysis of a biopsy (removal of a fragment of tissue).

Colposcopy

This assessment takes place in a gynaecological practice. The doctor examines the surface of the cervix and vagina using a coloscope, which is a powerful magnifying glass with a light at its tip. This exam examines the abnormal areas, deposits liquids that reveal precancerous lesions, and takes biopsies (samples of a thin fragment of the cervix). Colposcopy is not painful but may cause discomfort during the procedure.
Conical biopsy or conization

This examination consists of removing a conical fragment of the hard-to-reach lesions of the cervix. The conization is performed under local or general anaesthesia. The aim is essentially diagnostic, but in some cases the conical biopsy removes all the cells presumed to be cancerous and in this case no further treatment will be necessary.

Anatomo-Pathological Examination

It is the microscopic examination of tissue fragments obtained by biopsy or conization. It is the standard test to confirm the diagnosis of cervical cancer.

The analyses performed on the cells help to define the cancer-causing cell and its characteristics.

Therapeutic Management of the cervix

The choice of treatment in cervical cancer depends on 2 criteria:

  • Characteristics of the tumor: including size, location, stage and grade of tumor;
  • The general condition of the patient.

Using these criteria, health professionals develop a protocol of care in a multidisciplinary consultation meeting (MDC). The opinion of the RCP is then submitted to the patient by the referring physician. It is therefore a consultation between patient and doctor that gives the “green light” to therapeutic management. The patient validates the opinion of the RCP by his or her informed consent, i.e. by having understood the issues and risks related to the proposed treatments.

The treatment of cervical cancer is organized around 3 axes: surgery, radiotherapy and chemotherapy. The protocols can be used alone or in combination and aim, depending on the case, to: destroy the tumour(s), reduce the risk of relapse, slow down the development of the tumour and treat the symptoms linked to the disease.

Surgery

This therapeutic axis is mainly used to treat local and small tumours of the cervix. Surgery removes the entire tumour and thus cures the disease. Several interventions exist. The choice is made according to the extent of the cancer, but also according to the age and the patient’s possible desire for pregnancy.

Extended colpohysterectomy

It is the most performed surgical procedure for the treatment of cervical cancer. During this operation, the surgeon removes the entire uterus and the upper part of the vagina. In addition, the ovaries are also frequently removed. This treatment is only possible for patients with a limited cervical tumour smaller than 4 cm.

The removal of ganglionic networks

Cancers can spread throughout the body through the lymph nodes. The removal of the lymph nodes near the uterus limits the risk of spreading the disease as well as the risk of relapse.

Hysterectomy

During this operation, the surgeon removes only the uterus, leaving the upper part of the vagina intact. Hysterectomy is a treatment indicated for small tumours that are very limited to the cervix.
Trachelectomy

A trachelectomy involves removing only the cervix. Once the removal is complete, the surgeon uses special sutures called cerclage to partially close the uterus where the cervix used to be. This new opening allows blood to drain out during menstruation. [/column]

This operation is only possible in tumours that are limited to the cervix and do not exceed 2 centimetres in size. This surgery is called conservative because it preserves the uterus and therefore the fertility of young women wishing to become pregnant in the future.

Radiotherapy

Radiotherapy is a local treatment using high-energy ionizing radiation to destroy cancer cells. This therapeutic method makes it possible to very precisely target an area to be treated in order to irradiate the tumour while preserving the surrounding healthy tissue as much as possible. Two types of radiation therapy can be used in cervical cancer.

External radiotherapy: is a technique in which the source of the radiation is outside the patient. The radiation beam is directed against the patient’s tumour, guided by landmarks. Several sessions per week are necessary, spread over a few months.

Internal radiotherapy or brachytherapy: consists of placing an applicator containing the radiation source in the vagina and in contact with the tumour. The irradiation of the cancer is therefore continuous. This therapy can be used in cervical cancer, especially before surgery to reduce the size of the tumour. During brachytherapy, the patient is considered “radioactive” because the source of radiation is in her body.

Chemotherapy

Chemotherapy comprises all the drug therapies acting on cancer cells with the aim of either destroying them or limiting their multiplication. It is the only therapeutic axis that acts on the whole organism. Chemotherapy treatments can be used by the venous or oral route depending on the molecules used.

In cervical cancer, chemotherapy is indicated either to reduce the size of a tumour in order to increase the success of a surgical operation, or in the treatment of cancers at high risk of spreading or metastatic. The most commonly used molecules are :

  • 5-FluoroUracil (5-FU): which is an anti-cancer agent that blocks the tumour’s DNA synthesis, preventing it from multiplying.
  • Platinum salts: which are anti-cancer drugs that can bind to DNA and stop the proliferation of cancer cells.

sources

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Health

Type 2 Diabetes: Symptoms, Causes, Diagnosis, and Treatment

By: Dr. Fabienne Langlois, Endocrinologist


Type 2 diabetes is a disease characterized by chronic hyperglycemia, which means too much glucose (sugar) in the blood. It usually occurs in older adults and is more common in people who are obese or overweight.

In a healthy individual, blood sugar control is achieved through insulin, a hormone secreted by the pancreas. Insulin allows sugar to enter the cells to be used as fuel, particularly in the muscles and liver. In a person with type 2 diabetes, the body becomes unable to regulate blood sugar, or the level of glucose in the blood. This is when blood glucose levels rise (called hyperglycemia). In the long term, if blood sugar levels are not lowered by treatment, this can cause serious health problems, especially cardiovascular problems.

This chronic disease requires individualized treatment and close monitoring by the affected person and the medical team. Healthy lifestyle habits are the basis of treatment. If these habits are not enough to lower blood sugar levels, medication may be used.

There are 2 main forms of diabetes, type 1 diabetes and type 2 diabetes, both characterized by chronic hyperglycemia.

Type 1 diabetes occurs in young people and often appears in childhood. It is caused by autoimmune destruction of the pancreas, which no longer produces insulin. The cause is poorly known and there is no prevention currently possible. People affected are therefore dependent on insulin, which must be administered by injection.

Type 2 diabetes, which accounts for 90% of diabetes cases, occurs later in life. It is mainly due to a state of insulin resistance and is associated with being overweight.

A disease in Strong Progression

The number of people with type 2 diabetes is steadily increasing and this trend is attributed to the “Western” lifestyle, which is associated with sedentary living and obesity, as well as an aging population. Globally, the International Diabetes Federation predicts that the number of people with diabetes could increase from 285 million in 2010 to 438 million in 2030.

In Canada, in 2009, 6% of people over the age of 12 years reported having diabetes. This rate increases with age, reaching nearly 18% among those 65 years and older. In total, more than 9 million Canadians have diabetes or prediabetes, including 650,000 Quebecers. In addition, many cases of diabetes are unknown because they are not detected.

Type 2 diabetes generally manifests itself after the age of 40, but is now affecting more and more children and adolescents because of obesity, which is affecting more and more young people.

Causes

Diabetes results from a combination of genetic, environmental and lifestyle factors. In general, each person carries a hereditary baggage that predisposes them to diabetes or protects them from it. Researchers now know several genes that put an individual at risk of developing type 2 diabetes. In people who are genetically predisposed to the disease, it is generally overweight and particularly the accumulation of fat in the organs of the abdomen that leads to insulin resistance, the first step towards type 2 diabetes.

Initially, to compensate for insulin resistance, the pancreas starts to produce more insulin. However, over time, the pancreas becomes depleted and insulin secretion decreases. As a result, there is a relative lack of insulin and blood glucose levels remain continuously high.

Type 2 diabetes is therefore the result of 2 phenomena: firstly, resistance to insulin, and secondly, the exhaustion of the pancreas.

Diagnosis

Because type 2 diabetes rarely has early symptoms, it is often discovered incidentally during a routine medical examination.

Blood glucose tests can detect it: a fasting or random blood glucose test and sometimes a test for induced hyperglycemia. The latter test consists of a blood glucose reading 2 hours after ingesting a sweet juice containing 75 g of glucose. Fasting blood glucose levels often rise gradually over the years from a normal level to an intermediate state of prediabetes and then to the diabetic threshold.

Blood glucose levels can be measured by taking a blood sample or estimated using a blood glucose meter (glucometer), which allows the blood glucose level to be analysed on a drop of blood taken from the fingertip.

Even if the results are normal, it is usually recommended that these tests be done at regular intervals to detect disease as early as possible.

Potential Complications

For information on acute complications (hypoglycemia and hyperglycemia due to treatment adjustment and hyperosmolar hyperglycemia syndrome in untreated diabetics), see our Diabetes Fact Sheet (Overview).

In the long term, many diabetics see their health condition worsen as a result of their disease, especially if the diabetes is not well controlled and monitored. Chronically high blood sugar levels gradually damage nerves and blood vessels, mainly in the eyes and kidneys. Diabetes can lead to cardiovascular disease, irreversible vision loss, pain due to nerve damage or kidney failure. For more information, see our Diabetes Complications fact sheet.

Symptoms of type 2 diabetes

In its early stages, type 2 diabetes causes few or no symptoms. It can go unnoticed for many years. However, some people may experience symptoms caused by high blood sugar, such as :

  • A frequent urge to urinate, especially at night. The kidneys produce more urine to try to eliminate excess glucose from the blood;
  • An increase in hunger and thirst, with a dry mouth feeling;
  • Excessive drowsiness, especially after meals;
  • Blurred vision;
  • More frequent bacterial or fungal infections (urinary tract infections, vaginitis, etc.).

Risk Factors for Type 2 Diabetes

Persons at Risk

  • People who have a first-degree relative (mother, father, brother or sister) with type 2 diabetes;
  • People who are obese or overweight, especially when the fat is concentrated in the abdomen rather than on the hips and thighs. This is because the fat in the organs of the abdomen (especially the liver) is the fat that interferes the most with insulin function. More than 80% of type 2 diabetics are overweight;
  • Certain populations are at higher risk, including Africans, Latin Americans, Asians and North American indigenous populations.

Risk Factors

  • Being over 40 years old. Type 2 diabetes affects mostly adults, and its prevalence increases with age;
  • Have a sedentary lifestyle and consume too many calories;
  • For women, having had gestational diabetes or having given birth to a baby weighing more than 4 kg;

Have a metabolic syndrome. In the clinic, the physician will assess the presence of the following factors (3 are sufficient to diagnose this syndrome):

  • abdominal obesity, determined by measuring waist circumference;
  • high blood triglycerides;
  • Low blood HDL (“good”) cholesterol;
  • High blood pressure;
  • High fasting blood sugar.

Prevention of Type 2 Dabetes

Screening measures

The need for screening for diabetes in the absence of symptoms will be assessed with the physician.

The earlier the disease is detected – even before the onset of symptoms – and the earlier intervention to restore normal blood glucose levels, the lower the risk of complications (cardiovascular, eye, kidney or neurological disorders, etc.). There is growing evidence of the effectiveness of early intervention.

Here are some recommendations: :

  • Assessment of the risk of diabetes in adults should be done by the physician at the time of the annual check-up;
  • Fasting blood glucose testing should be undertaken every 3 years in all adults 40 years of age and older, with or without symptoms. This screening should be done earlier or more frequently when risk factors have been found. A test for induced hyperglycemia may be undertaken for further analysis to establish the diagnosis;
  • Screening for the disease in high-risk children every 2 years is advised.

Basic preventive measures: Weight control, healthy eating and exercise

Type 2 diabetes can be prevented by simple means. One study, the Diabetes Prevention Program, showed that at-risk individuals who participated in 30 minutes of physical activity per day and were able to lose 5% to 7% of their weight decreased their risk of developing diabetes by 58%.

Being overweight increases insulin requirements and overstrains the pancreas. A person’s healthy weight is determined by their body mass index (BMI). Calculate yours with our Body Mass Index (BMI) and Waist Circumference test. It’s not a question of aiming for a healthy weight at all costs, but a weight loss of 5% to 10% in 6 months already provides significant health benefits.

A healthy and varied diet helps maintain a healthy weight. It also helps maintain a relatively stable blood sugar level throughout the day, as well as good blood pressure. To do this, eat as many as possible 3 meals a day at regular times, avoid excess animal fat and added sugars (glucose, fructose, dextrose, etc.) and favour foods rich in fibre. For an overview of the basic principles to follow, see How to eat well?

Regular physical activity also contributes to maintaining a healthy weight or to eliminating excess weight if necessary. Being active also helps insulin work more effectively. It is recommended to be active for at least 2.5 hours a week, spreading physical activity throughout the week in periods of at least 10 minutes at a time (brisk walking, swimming, jogging, cycling, etc.). It is important to start gradually and gradually increase the duration and intensity of the activity. Physical activity in itself can significantly reduce the risk of becoming diabetic.

Measures to prevent complications

It is important that the antidiabetic treatment is well adjusted. Adequate control of blood glucose levels prevents complications. To ensure that treatment is effective, regular self-monitoring of blood glucose levels with a blood glucose meter and medical follow-up are essential. Your doctor will use the level of glycated or glycosylated hemoglobin (HbA1c) in your blood (measured at least twice a year), which reflects the average blood glucose levels over the last 3 months.

Blood glucose targets to aim for that reflect good control :

  • a blood glucose level of 4 mmol/l to 7 mmol/l before meals;
  • a blood glucose level between 7 and 10 mmol/l 2 hours after a meal;
  • a glycated hemoglobin level of less than 7%.

Medical Treatments for Type 2 Diabetes

Diabetics can expect to lead an active, independent and dynamic life without any limitations. It remains important to respect certain basic principles, in particular with regard to :

  • an appropriate diet;
  • the adoption of an active lifestyle;
  • monitoring of capillary blood glucose levels.

For more details on lifestyle management for type 2 diabetes, please see our Diabetes Overview fact sheet, where you will find :

  • A diagram of glucose absorption;
  • a video showing how to use a blood glucose meter;
  • a table of optimal blood glucose values for teenagers and adults with diabetes;
  • an eating plan (see also our Special Diet: Diabetes fact sheet).
  • Suggestions for physical exercise;
  • Ways to manage stress.

For some people, regular adherence to this lifestyle will be enough to control blood sugar levels, while for others, medication will also be necessary. The goal of treatment is to keep blood glucose (sugar) levels within normal ranges. The means to achieve this are different for each person.

Drugs

There is no cure for diabetes. It is a chronic disease and lifelong treatment is necessary. However, better nutrition and regular physical activity is a real way to treat diabetes and can help avoid the need for medication. If these measures are not enough, doctors may prescribe one or more of the following diabetes medications, all of which have the effect of lowering blood sugar levels or helping to control them.

  • Metformin (Glucophage® or Glumetza®) is the cornerstone of treatment for the vast majority of people with type 2 diabetes. It works by decreasing insulin resistance, which helps the body use glucose more efficiently without the risk of hypoglycemia. It also promotes weight loss;
  • Medications that increase insulin secretion (or insulin secretors) include sulfonylureas (Diabeta®, Diamicron®, Diabeta®) and glinides (Starlix®, GlucoNorm®). They directly stimulate insulin production by the pancreas through various mechanisms. They are very effective in controlling blood sugar levels, but with the potential risk of causing hypoglycemia;
  • Thiazolidinediones (or glitazones), a class of drugs that includes rosiglitazone (Avandia®) and pioglitazone (Actos®), improve blood glucose levels by decreasing insulin resistance. These drugs are being prescribed less and less in Canada and warnings have been issued by regulatory agencies because of the risk of heart attacks and fractures in certain populations. It should be noted that rosiglitazone-based drugs were withdrawn from the European market at the end of 2010 due to their cardiovascular adverse effects;
  • Acarbose, which is an alpha-glucosidase inhibitor (Glucobay®), reduces the absorption of carbohydrates in the gut. They must be taken with a meal to be effective and may cause bloating and flatulence caused by unabsorbed sugars;
  • Incretinomimetics (or incretins) are a new family of drugs that includes Januvia® (sitagliptin), Byetta® (exaenatide), Onglyza® (saxagliptin) and Victoza® (liraglutide). They work by increasing insulin secretion after a meal without causing hypoglycemia. Oral medications (sitagliptin and saxagliptin) have a neutral effect on weight. Victoza® is a newcomer to the market, is administered by injection and is associated with weight loss. However, it is not indicated for first-line use and its long-term effects and safety are unknown.

Weight-loss medications such as orlistat (Xenical®) may be considered in diabetic patients suffering from obesity. They are useful for improving blood glucose levels by allowing weight loss. However, their cost is high and they are not appropriate for all patients.

Insulin treatment with injections is a very valid option, although it is often used after failure of oral medications. It can also be used temporarily, for example, in cases of severe hyperglycemia, infection, hospitalization, or surgery. Insulin injections may be required when medications are no longer sufficient because insulin secretion decreases over time in people with type 2 diabetes. Injections are usually given once a day, often in the evening. Some people can also be treated with an insulin pump.

Type 2 Diabetes – Our Doctor’s Opinion

If you have type 2 diabetes, you can have some control over your disease by taking an active role in your treatment. Diabetes is a demanding disease, but it has the advantage of being able to change the course of the disease by being involved in its treatment. You will reap long-term benefits.

There are many tools to improve your blood glucose levels, and adopting a healthy lifestyle is the basis of treatment. It is also important to monitor your blood glucose levels regularly. This will tell you right away if your diabetes is well controlled or not. The frequency of monitoring varies from person to person, but should be increased at least 1 week before your doctor’s appointment to allow him or her to analyze changes in your capillary blood glucose levels during the day and to better adjust your treatment. In addition, the prevention of complications related to diabetes involves, among other things, stopping smoking and controlling blood pressure and cholesterol levels, which your doctor will assess.

The goal is to achieve and maintain an acceptable average blood sugar level without hypoglycemia. This average is reflected in the measurement of glycated hemoglobin. You can ask your doctor to share your results with you so that you know where you stand in relation to the targets.

Finally, several avenues have been studied to prevent this disease, including medications. However, simple healthy eating and exercise are the most effective. These recommendations are achievable and free of side effects, but more importantly, they provide health benefits that go far beyond diabetes prevention.

Type 2 diabetes – Complementary Approaches

Warning. Self-medication for diabetes can cause serious problems. When you start treatment that changes your blood glucose levels, you must monitor your blood glucose levels very closely. It is also necessary to inform your doctor so that he or she can review the dosage of conventional blood-glucose-lowering drugs if necessary.

In Process

  • Ginseng (Panax ginseng and Panax quinquefolium). A growing number of good quality studies are validating the traditional use of ginseng roots and rootlets to treat diabetes, but trials involving a larger number of subjects would allow more reliable conclusions to be reached4. 4 Ginseng is thought to help normalize blood glucose levels in people with diabetes,28 particularly after meals.
  • Psyllium (Plantago ovata). The main effect of taking psyllium with a meal is to lower the total glycemic index of the meal. This causes glucose and insulin levels to decrease by 10% to 20% after the meal. Psyllium works in a similar way to acarbose, a medication used by some people with type 2 diabetes: it slows down the absorption of carbohydrates into the digestive system. A 2010 review of 7 randomized studies concluded that psyllium is an interesting treatment option for type 2 diabetics who are on medication and still have high blood glucose levels after meals.
  • Glucomannan. a soluble fibre, similar to psyllium but even more absorbent and emollient than psyllium. It is made from konjac flour (a type of tuber) in a purified form. The results of several clinical trials indicate that glucomannan may be useful in reducing or controlling blood sugar levels in people with diabetes or obesity.
  • Oats (Avena sativa). Research indicates that consumption of oatmeal helps to prevent the rise in blood glucose levels following a meal (postprandial hyperglycemia). Oatmeal may also help to control blood glucose levels over the long term. Like psyllium, oatmeal contains high levels of soluble fibre, which slows gastric emptying.
  • Chromium. a trace element essential to human health, naturally present in many foods. In particular, it increases tissue sensitivity to insulin, which helps normalize blood sugar levels. In 2007, a meta-analysis of 41 trials (including 7 in patients with type 2 diabetes) showed that chromium supplements decreased glycated hemoglobin levels by 0.6% and fasting blood glucose levels by 1 mmol/L41. However, the use of chromium supplements (from 200 μg to 1,000 μg per day) by people with diabetes remains controversial given the highly variable quality of the studies conducted to date.
  • Fenugreek (Trigonella foenum-graecum). The results of a few clinical studies in diabetics have shown that fenugreek seeds may help regulate blood glucose levels in type 216-18 diabetes. Although promising, these trials had a number of flaws, so it is not possible at this time to suggest a treatment protocol19.
  • Cinnamon (Cinnamomum verum or C. cassia). Some small studies have shown that cinnamon can reduce blood glucose levels in people with diabetes, but more comprehensive studies will be needed to confirm these results.
  • Tai-chi. Some researchers have speculated that tai-chi may help regulate blood glucose levels in people with diabetes. To date, the various studies have presented contradictory results. Some studies show improvements, others do not.
  • Aloe (Aloe vera). Aloe is one of the plants to which Ayurvedic medicine (from India) attributes hypoglycemic or anti-diabetic properties. Studies conducted to date tend to confirm this use, but are few in number. Dosage: Although the efficacy of the gel as a hypoglycemic substance is not clearly established, it is usually recommended to take 1 tbsp twice a day before meals.
  • Blueberry or bilberry (Vaccinium myrtilloides and Vaccinium myrtillus). In Europe, blueberry leaves have been used for more than 1,000 years to lower blood glucose levels. Tests carried out on animals tend to confirm this traditional use. However, the use of blueberry leaves for this disease has not been tested on humans. Dosage: Practitioners recommend infusing 10 g of leaves in 1 litre of boiling water and taking 2 to 3 cups of this infusion per day.
  • Gymnema (Gymnema sylvestre). In many countries (India, Japan, Vietnam, Australia…), traditional doctors use gymnnema to lower glucose levels in diabetics24,28,29. However, no double-blind clinical trial with placebo has been conducted, so there is no scientifically valid evidence of its effectiveness. Dosage: Rather than dried leaves, a standardized 24% gymnemic acid extract is used nowadays. This extract, often referred to as GS4, is the raw material for the majority of commercial products. Take 200 mg to 300 mg of this extract twice a day with food.
  • Momordica (Momordica charantia). Momordica, also known as margose, is a tropical climbing plant that produces fruits that look like cucumbers. Traditionally, several peoples have used its fruit to treat a variety of ailments. The consumption of fresh fruit juice is believed to help regulate blood sugar levels in diabetics, for example, by lowering blood sugar levels. This effect has been confirmed by several in vitro and animal tests. Studies in humans are at the preliminary stage. Dosage: Traditionally, it is recommended to drink 25 ml to 33 ml of fresh fruit juice (about the equivalent of 1 fruit) 2 to 3 times a day before meals.
  • Nopal (Opuntia ficus indica). The stems of the nopal, a cactus from the desert regions of Mexico, have been used in traditional medicine to reduce fasting blood glucose in diabetics. This effect has been observed in a few clinical trials conducted by Mexican researchers. Rich in dietary fibre, nopal is believed to act mainly by reducing glucose absorption. Dosage: In studies with positive results, 500 g of roasted nopal flesh was used per day.
  • Naturopathy. The American naturopath J.E. Pizzorno suggests, among other things, that diabetics should take a multivitamin and mineral supplement,36 as the disease would lead to an increased need for nutrients. In his experience, this practice improves blood glucose control and helps prevent the major complications of diabetes. A double-blind, placebo-controlled study of 130 subjects (45 years and older) showed that people with diabetes who took multivitamins for one year had fewer respiratory infections and flu than untreated diabetics.

Moreover, the naturopath considers important that diabetics consume a large quantity of flavonoids, in food form, for their antioxidant effect. Indeed, there are more oxidation and inflammation reactions in the body of people with diabetes. Flavonoids are found mainly in fruits and vegetables (artichoke, onion, asparagus, red cabbage and spinach) and in even greater quantities in berries. They are also found in the form of supplements.

Type 2 Diabetes – Websites and Support Groups

These do not treat diabetes but could improve overall health. See our Naturopathy fact sheet.

Canada

Diabetes Quebec
The mission of this association is to inform about diabetes and to promote research on this disease. Diabetes Québec also provides services and defends the socio-economic interests of people with the disease.
www.diabete.qc.ca
See suggestions for recipe books in the Books and Materials section: www.diabete.qc.ca

Canadian Diabetes Association (Association canadienne du diabète)
Very complete site in English (some documents are available in French): www.diabetes.ca
Of particular note on this site, about the exercise: www.diabetes.ca

Health Canada – Diabetes
An up-to-date dossier on diabetes, in French and English.
www.phac-aspc.qc.ca

Programs and services for people with diabetes: www.phac-aspc.qc.ca
Prevention program for Aboriginal populations: www.phac-aspc.qc.ca

Quebec Government Health Guide
To learn more about drugs: how to take them, what are the contraindications and possible interactions, etc., click here.
www.guidesante.gouv.qc.ca

United States

American Diabetes Association
www.diabetes.org

International

International Diabetes Federation: For its news articles, presentation of epidemiological data, announcement of international congresses, etc., it is the ideal partner for the company. (in English only, French and Spanish translations in development).
www.idf.org

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